Long Covid – info and links indicating major impact

Evidence is snowballing that Long Covid is also a serious issue, even affecting people in whom the disease initially appeared mild.

While deaths from Covid have proven most newsworthy, evidence is snowballing that Long Covid is also a serious issue, even affecting people in whom the disease initially appeared mild. Here, a few snippets from related articles and Twitter threads, links to these so may be of some use to anyone interested.

You really don’t want long covid

https://twitter.com/risahoshinoMD/status/1505381772833574916

A systemic illness that has debilitated millions

Long COVID is a multisystemic illness encompassing ME/CFS, dysautonomia, impacts on multiple organ systems, and vascular and clotting abnormalities. It has already debilitated millions of individuals worldwide, and that number is continuing to grow. On the basis of more than 2 years of research on long COVID and decades of research on conditions such as ME/CFS, a significant proportion of individuals with long COVID may have lifelong disabilities if no action is taken. Diagnostic and treatment options are currently insufficient, and many clinical trials are urgently needed to rigorously test treatments that address hypothesized underlying biological mechanisms, including viral persistence, neuroinflammation, excessive blood clotting and autoimmunity.

Long COVID: major findings, mechanisms and recommendations

Chance of long Covid increases with reinfections

the study reported that long COVID diagnoses during the Omicron epoch occurred much closer to the index date of the infection or reinfection, and the number of long COVID diagnoses also showed an increase after reinfections with recent variants.

Study explores incidence, severity, and long COVID associations of SARS-CoV-2 reinfections

Disability to affect a generation

Long Covid could create a generation affected by disability, with people forced out of their homes and work, and some even driven to suicide, a leading expert has warned.

In an exclusive interview with the Guardian, Prof Danny Altmann – an immunologist at Imperial College London – said that the UK’s current approach to Covid fails to take the impact of infections sufficiently seriously, adding that more needs to be done to aid diagnosis and treatment of long Covid.

“It’s kind of an anathema to me that we’ve kind of thrown in the towel on control of Omicron wave infections and have said ‘it’s endemic, and we don’t care any more, because it’s very benign’,” he said. “It just isn’t. And there are new people joining the long Covid support groups all the time with their disabilities. It’s really not OK, and it’s heartbreaking.”

The Guardian: Long Covid could create a generation affected by disability, expert warns

Long Covid has multiple impacts in body

The paper is More than 50 long-term effects of COVID-19: a systematic review and meta-analysis

Vaccines do not fully protect against long covid

https://twitter.com/dgurdasani1/status/1506745795206336512

Brain fog among long covid symptoms

How common are cognitive symptoms of long COVID? on Medical News Today includes:

As time goes on, [however,] there is more and more focus on the lingering effects of COVID-19, which experts refer to as long COVID.

For instance, there are reports of concentration and memory issues. A new study from the Universities of Cambridge and Exeter in the United Kingdom investigates just how common such problems are.

According to the study, 78% of people who reported they had long COVID symptoms during the study stated they experienced difficulties with concentration.

Also:

A large study comparing brain scans from the same individuals before and after SARS-CoV-2 infection suggests that brain changes could be a lingering outcome of even mild COVID-19. Writing in Nature, researchers at Oxford University’s Wellcome Centre for Integrative Neuroimaging reported that several months after study participants had SARS-CoV-2 infections, they had more gray matter loss and tissue abnormalities, mainly in the areas of the brain associated with smell, and more brain size shrinkage than participants who hadn’t been infected with the virus.

Even Mild COVID-19 May Change the Brain

Reduced blood flow to brain

The paper linked to here has the clunky title Orthostatic Intolerance in Long-Haul COVID after SARS-CoV-2: A Case-Control Comparison with Post-EBV and Insidious-Onset Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

Signs of autoimmune disease in people with Long Covid

Blood samples drawn from patients with long COVID who are still suffering from fatigue and shortness of breath after a year show signs of autoimmune disease in those patients, according to a study published today in the European Respiratory Journal.

Autoimmune disease occurs when the immune system mistakenly attacks healthy parts of the body, instead of defending the body against disease. It causes conditions such as rheumatoid arthritis and lupus.

Long COVID patients show signs of autoimmune disease a year after infection

Immune system damaged by Covid?

A person at the centre of the storm, sounding alarms about T cell “dysregulation” since the early days of the pandemic, has been a U.S. immunologist named Anthony Leonardi.

By dysregulation Leonardi means three effects of COVID:

  • The hyperactivation of many T cells, which can prematurely age them
  • The exuberant function of those hyperactivated T cells, which can then cause organ damage
  • The exhaustion of those hyperactivated T cells, which implies they aren’t winning the battle against viral proteins they are supposed to defeat.

In other words, argues Leonardi, T cells are becoming hyperactivated by SARS-CoV-2 and are prematurely aging, harming organs, and becoming exhausted trying to rid the body of an immune-evasive virus. 

If he is right, then no, we cannot assume that T cells will save us — not as thoroughly, at least, as we’ve been led to believe.

What If COVID Reinfections Wear Down Our Immunity?

Long Covid depleting UK workforce

Just like a cold/mild flu … Not!

//Since the start of the pandemic, cumulatively 2.9 million people of working age (7% of the total) in the UK have had, or still have, Long COVID. This figure will continue to rise due to very high infection rates in the Omicron wave. Since the beginning of the pandemic, economic inactivity due to long-term sickness has risen by 120,900 among the working-age population, fuelling the UK’s current labour shortage. An estimated 80,000 people have left employment due to Long COVID.//

The impact of Long COVID on the UK workforce

Vitamin C and l-arginine may help

Worth a try? – I’m taking, after covid, in hope they may be beneficial.

Following a 30-day treatment in both groups, the survey revealed that patients in the L-Arginine + Vitamin C treatment arm had significantly lower scores compared to patients who had received the multivitamin combination. 

Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey

Covid articles by DocMartin

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